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Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis

28 Jan 2020

Abstract excerpt

CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the escape of these cancer cells from macrophage-mediated phagocytosis. In recent years, CD47 has been shown to be highly expressed by various types of solid tumors and to be associated with poor patient prognosis in various types of...

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PMID: 32082311
DOI: 10.3389/fimmu.2020.00018

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