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Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases

15 Jul 2025

Abstract excerpt

With the intensification of global aging, the incidence of age-related diseases (including cardiovascular, neurodegenerative, and musculoskeletal disorders) has been on the rise, and cellular senescence is identified as the core driving mechanism. Cellular senescence is characterized by irreversible cell cycle arrest, which is caused by telomere shortening, imbalance in DNA damage repair, and mitochondrial...

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PMID: 40722797
DOI: 10.3390/biomedicines13071727

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