Article

ACTOR: a latent Dirichlet model to compare expressed isoform proportions to a reference panel

2019-11-26

Abstract excerpt

The relative proportion of RNA isoforms expressed for a given gene has been associated with disease states in cancer, retinal diseases, and neurological disorders. Examination of relative isoform proportions can help determine biological mechanisms, but such analyses often require a per-gene investigation of splicing patterns. Leveraging large public datasets produced by genomic consortia as a reference, one can c...

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Literature Corpus work: 9812c157-aa68-5756-8aa8-454f86f92404
DOI: 10.1101/856401

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