Article

Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues

2021-10-28

Abstract excerpt

Expression quantitative trait loci (eQTLs), or single nucleotide polymorphisms (SNPs) that affect average gene expression levels, provide important insights into context-specific gene regulation. Classic eQTL analyses use one-to-one association tests, which test gene-variant pairs individually and ignore correlations induced by gene regulatory networks and linkage disequilibrium. Probabilistic topic models, such a...

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Literature Corpus work: 5d0feee1-5754-538b-afc2-e566ccd4f1d0
DOI: 10.1101/2021.10.27.466156

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