Assessing allele-specific expression across multiple tissues from RNA-seq read data.

Abstract excerpt

MOTIVATION: RNA sequencing enables allele-specific expression (ASE) studies that complement standard genotype expression studies for common variants and, importantly, also allow measuring the regulatory impact of rare variants. The Genotype-Tissue Expression (GTEx) project is collecting RNA-seq data on multiple tissues of a same set of individuals and novel methods are required for the analysis of these data....

Topics

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• Alleles
• Extracellular Matrix Proteins
• High-Throughput Nucleotide Sequencing
• Organ Specificity
• Polymorphism, Single Nucleotide