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Article

A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes.

BMC genomics - 11 Jan 2016

Nariai Naoki, Kojima Kaname, Mimori Takahiro, Kawai Yosuke, Nagasaki Masao

Abstract excerpt

BACKGROUND: RNA-sequencing (RNA-Seq) has become a popular tool for transcriptome profiling in mammals. However, accurate estimation of allele-specific expression (ASE) based on alignments of reads to the reference genome is challenging, because it contains only one allele on a mosaic haploid genome. Even with the information of diploid genome sequences, precise alignment of reads to the correct allele is...

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PMID: 26818838
DOI: 10.1186/s12864-015-2295-5
PMCID: PMC4895278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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