Article
FUN-LDA: A Latent Dirichlet Allocation Model for Predicting Tissue-Specific Functional Effects of Noncoding Variation: Methods and Applications.
American journal of human genetics - 3 May 2018
Backenroth Daniel, He Zihuai, Kiryluk Krzysztof, Boeva Valentina, Pethukova Lynn, Khurana Ekta, Christiano Angela, Buxbaum Joseph D, Ionita-Laza Iuliana
Abstract excerpt
We describe a method based on a latent Dirichlet allocation model for predicting functional effects of noncoding genetic variants in a cell-type- and/or tissue-specific way (FUN-LDA). Using this unsupervised approach, we predict tissue-specific functional effects for every position in the human genome in 127 different tissues and cell types. We demonstrate the usefulness of our predictions by using several...
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