Article

Regulator-derived growth and fitness costs of <i>Salmonella</i> SPI-2 expression are environment specific and T3SS independent

2026-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Bacterial pathogens must evolve regulatory mechanisms that balance the necessity of virulence genes with the costs associated with their expression. Salmonella Pathogenicity Island-2 (SPI-2) is a genomic locus that encodes a Type 3 Secretion System (T3SS) and secreted effectors necessary for intracellular survival and replication. Recent work has shown that SPI-2 is expressed heterogeneously, s...

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Literature Corpus work: 97e31763-7b66-579a-bb62-6765fa28cd7b
DOI: 10.64898/2026.04.10.717833

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