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Article

Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation.

PLoS pathogens - 1 Aug 2026

McLelland Leah, Spratt Madison, Karki Dakshya, Marand Anika, Burt Miracle, Zhao Jonathan, Lane Keara

Abstract excerpt

Xenogeneic silencers, such as histone-like nucleoid structuring protein (H-NS), are critical for maintaining horizontally acquired genes in bacterial genomes and minimizing fitness costs associated with inappropriate expression. For bacterial pathogens, this has enabled the acquisition of costly virulence regulons, with H-NS balancing the need for tight silencing with rapid expression in host environments. For...

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Identifiers

PMID: 42574445
DOI: 10.1371/journal.ppat.1014488
PMCID: PMC13456270

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