Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneity.

Abstract excerpt

Gene regulatory networks often evolve in the face of environmental uncertainty, as stimuli are rarely precise and uniform enough to make all-or-nothing responses advantageous. Virulence gene regulation in intracellular bacterial pathogens is shaped by unique selective pressures to resolve this uncertainty, as host environments are dynamic, hostile, and heterogeneous. Here, we investigate the regulation of...

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