Back to search

Article

Microbiota-derived metabolites inhibit <i>Salmonella</i> virulent subpopulation development by acting on single-cell behaviors

2021-02-15

Abstract excerpt

Salmonella spp. express Salmonella pathogenicity island 1 (SPI-1) genes to mediate the initial phase of interaction with host cells. Prior studies indicate short-chain fatty acids, microbial metabolites at high concentrations in the gastrointestinal tract, limit SPI-1 gene expression. A number of reports show only a subset of Salmonella cells in a population express these genes, suggesting short-chain fatty acid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
23fe3d1c-f275-5a55-b0b5-9dceaf2bc0dc
DOI
10.1101/2021.02.14.430798
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Microbiota-derived metabolites inhibit <i>Salmonella</i> virulent subpopulation development by acting on single-cell behaviorsDOI 10.1101/2021.02.14.430798
Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model systemSemantic proximity
Differences in Host Cell Invasion and Salmonella Pathogenicity Island 1 Expression between Salmonella enterica Serovar Paratyphi A and Nontyphoidal <i>S</i> . TyphimuriumSemantic proximity
Regulator-derived growth and fitness costs of <i>Salmonella</i> SPI-2 expression are environment specific and T3SS independentSemantic proximity
Bile Acids Function Synergistically To Repress Invasion Gene Expression in Salmonella by Destabilizing the Invasion Regulator HilDSemantic proximity
The intestinal fatty acid propionate inhibits <i><scp>S</scp>almonella</i> invasion through the post‐translational control of <scp><scp>HilD</scp></scp>Semantic proximity
Intracellular <i>Salmonella</i> Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular <i>S</i> . TyphimuriumSemantic proximity
R-loop imbalance compromises virulence in <i>Salmonella enterica</i>Semantic proximity
Methylthioadenosine reduces host inflammatory response by suppressing <i>Salmonella</i> virulenceSemantic proximity
Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of <i>Salmonella enterica</i>Semantic proximity
Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneitySemantic proximity
Colon cancer and cell transformation by clinical <i>Salmonella</i> strains are associated with bacterial virulence and intracellular fitnessSemantic proximity
Salmonella Intracellular Lifestyles and Their Impact on Host-to-Host TransmissionSemantic proximity
Select a neighboring publication to make it the new centre.