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<i>Salmonella</i> multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

2024-12-14

Abstract excerpt

Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulation of host cells through diverse mechanisms, but interdependency or redundancy between effectors complicates the discovery of effector phenotypes using single mutant strains. Here, we engineer six mutant strains to be...

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Identifiers and source

Literature Corpus work
6e906ec5-1933-5c32-a09e-9c1f448a8e8f
DOI
10.1101/2024.12.14.628483
Open publication

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<i>Salmonella</i> multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonizationDOI 10.1101/2024.12.14.628483
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