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Article

Silencing by H-NS potentiated the evolution of Salmonella.

PLoS pathogens - 1 Nov 2014

Ali Sabrina S, Soo Jeremy, Rao Chitong, Leung Andrea S, Ngai David Hon-Man, Ensminger Alexander W, Navarre William Wiley

Abstract excerpt

The bacterial H-NS protein silences expression from sequences with higher AT-content than the host genome and is believed to buffer the fitness consequences associated with foreign gene acquisition. Loss of H-NS results in severe growth defects in Salmonella, but the underlying reasons were unclear. An experimental evolution approach was employed to determine which secondary mutations could compensate for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25375226
DOI: 10.1371/journal.ppat.1004500
PMCID: PMC4223078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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