Article

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

2023-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Perturbed secretion of insulin and other pancreatic islet hormones is the main cause of type 2 diabetes (T2D). The islets harbor five cell types that are potentially altered differently by T2D. Whole-islet transcriptomics and single-cell RNA-sequencing (scRNAseq) studies have revealed differentially expressed genes without reaching consensus. Here, we demonstrate that unprecedented insights into...

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Literature Corpus work: 45c8888f-e84d-5e0d-96ca-b74709723e6f
DOI: 10.1101/2023.03.23.533985

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