Article

Mitochondrial and insulin gene expression in single cells shape pancreatic beta cells’ population divergence

2020-07-22

Abstract excerpt

Mitochondrial gene expression is pivotal to cell metabolism. Nevertheless, it is unknown whether it diverges within a given cell type. Here, we analysed single-cell RNA-seq experiments from ∼4600 human pancreatic alpha and beta cells, as well as ∼900 mouse beta cells. Cluster analysis revealed two distinct human beta cells populations, which diverged by mitochondrial (mtDNA) and nuclear DNA (nDNA)-encoded oxidativ...

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Literature Corpus work: d77e88df-9bd3-5ba6-85d8-1e1681439dfa
DOI: 10.1101/2020.07.21.213801

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