Article

A two-step mechanism for RIG-I activation by influenza virus mvRNAs

2025-01-04

Abstract excerpt

Influenza A virus (IAV) non-canonical replication products can be bound by host pathogen sensors, such as retinoic acid-inducible gene I (RIG-I). However, innate immune activation is infrequent in cell culture infection, in particular by adapted strains. Moreover, it is not understood why non-canonical IAV RNAs activate RIG-I in a sequence- or RNA structure-dependent manner. We therefore hypothesized that multiple...

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Literature Corpus work: 97c82ae8-95c0-5ec1-9d02-5d30cc82c6ac
DOI: 10.1101/2025.01.04.630666

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