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Article

Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1

11 Jun 2022

Abstract excerpt

Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation remains overlooked. Here, we characterize the landscape of endogenous ligands that engage RIG-I-like...

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PMID: 35789859
DOI: 10.1016/j.isci.2022.104599

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