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Article

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

17 Oct 2007

Abstract excerpt

Alpha/beta interferon immune defenses are essential for resistance to viruses and can be triggered through the actions of the cytoplasmic helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). Signaling by each is initiated by the recognition of viral products such as RNA and occurs through downstream interaction with the IPS-1 adaptor protein. We directly compared...

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PMID: 17942531
DOI: 10.1128/jvi.01080-07

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