Article

The NS1 protein of influenza B virus binds 5’-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response

2023-09-25

Abstract excerpt

<h4>SUMMARY</h4> Influenza A and B viruses overcome the host antiviral response to cause a contagious and often severe human respiratory disease. Here, integrative structural biology and biochemistry studies on non- structural protein 1 of influenza B virus (NS1B) reveal a previously unrecognized viral mechanism for innate immune evasion. Conserved basic groups of its C-terminal domain (NS1B-CTD) bind 5’- triphos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1cff2cf1-4abb-550c-8cd8-6823f7abf37a
DOI: 10.1101/2023.09.25.559316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The NS1 protein of influenza B virus binds 5’-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral responseDOI 10.1101/2023.09.25.559316Read

The NS1 protein of influenza B virus binds 5’-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral responseSemantic proximity Read

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host FactorSemantic proximity Read

Influenza Viruses Control the Vertebrate Type I Interferon System: Factors, Mechanisms, and ConsequencesSemantic proximity Read

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate ImmunitySemantic proximity Read

Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses.Semantic proximity Read

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.Semantic proximity Read

Influenza virus and cell signaling pathwaysSemantic proximity Read

Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene ISemantic proximity Read

The multifunctional NS1 protein of influenza A virusesSemantic proximity Read

Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta InterferonSemantic proximity Read

Evasion mechanisms of the type I interferons responses by influenza A virusSemantic proximity Read

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine designSemantic proximity Read