Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification, functional analysis, and clinical applications of defective viral genomes

17 Jul 2025

Abstract excerpt

Defective viral genomes (DVGs) are fragments derived from defective interfering particles (DIPs) that form during viral replication. They play important roles by interfering with complete virus replication and regulating host immune responses. Advances in high-throughput sequencing (HTS) and bioinformatic technology have significantly improved the ability to identify DIPs and DVGs. Their heterogeneity and dynamic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Bacteriophages and microbial interactions
Share to Herpesvirus Infections and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40746319
DOI: 10.3389/fmicb.2025.1642520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification, functional analysis, and clinical applications of defective viral genomesPMID 40746319Read ↗

DI-tector : defective interfering viral genomes’ detector for next-generation sequencing dataSemantic proximity Read ↗

Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteomeSemantic proximity Read ↗

SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon ResponsesSemantic proximity Read ↗

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infectionSemantic proximity Read ↗

Unveiling the biology of defective viral genomes in vitro and in vivo: implications for gene expression and pathogenesis of coronavirusSemantic proximity Read ↗

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.Semantic proximity Read ↗

The dynamic interactions between virus infections and nonsense-mediated decaySemantic proximity Read ↗

Innate Sensing of DNA Virus GenomesSemantic proximity Read ↗

The defective component of viral populationsSemantic proximity Read ↗

Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAiSemantic proximity Read ↗

Subgenomic Flaviviral RNAs of Dengue VirusesSemantic proximity Read ↗

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus GenomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.