Article

A Crispr Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis that Acts through Reduced mTOR Signalling

2019-04-18

Abstract excerpt

<h4>Introduction</h4> A greater understanding of molecular mechanisms underlying metastasis is necessary for development of new strategies to prevent and treat cancer. <h4>Methods</h4> We performed a genome-wide CRISPR/Cas9 knockout screen in MC38 colorectal cancer (CRC) cells transplanted orthotopically into mice to identify genes that promote metastasis. We undertook focussed molecular analyses to identify mec...

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Literature Corpus work: 97c3b12a-4554-5231-b5ba-f20cf0a9c477
DOI: 10.1101/613356

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