Article
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.
Genes & development - 15 Feb 2017
Boutin Adam T, Liao Wen-Ting, Wang Melody, Hwang Soyoon Sarah, Karpinets Tatiana V, Cheung Hannah, Chu Gerald C, Jiang Shan, Hu Jian, Chang Kyle, Vilar Eduardo, Song Xingzhi, Zhang Jianhua, Kopetz Scott, Futreal Andrew, Wang Y Alan, Kwong Lawrence N, DePinho Ronald A
Abstract excerpt
Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors activating mutations in the KRAS gene. To understand the role of oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Krasmut ) and conditional null alleles of Apc and Trp53 (iKAP). The iKAP model recapitulates tumor progression from adenoma through metastases....
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