Article

Combined Inhibition of Insulin Growth Factor 1 Receptor and Autophagy impede Colorectal Cancer Metastasis

2025-08-18

Abstract excerpt

<title>Abstract</title> <p>Insulin-like growth factor 1 (IGF-1) is known to promote cancer cell proliferation, but its role in metastasis remains incompletely understood. Autophagy, a key regulator of cancer cell behavior, plays a significant role in colorectal cancer (CRC) progression. Our previous transcriptomic analysis identified autophagy-related genes and insulin-like growth factor 1 receptor (IGF-1R) among...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18fb1c91-061d-5764-8a1d-3a40ce231424
DOI: 10.21203/rs.3.rs-7081271/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combined Inhibition of Insulin Growth Factor 1 Receptor and Autophagy impede Colorectal Cancer MetastasisDOI 10.21203/rs.3.rs-7081271/v1Read

Autophagy-related lncRNAs and exosomal lncRNAs in colorectal cancer: focusing on lncRNA-targeted strategiesSemantic proximity Read

Autophagy in colorectal cancer: Current understanding of mechanisms and future therapeutic directionsSemantic proximity Read

The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapySemantic proximity Read

The effect of miRNA and autophagy on colorectal cancerSemantic proximity Read

Selected Aspects of Chemoresistance Mechanisms in Colorectal Carcinoma—A Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and ApoptosisSemantic proximity Read

Clinicopathological significance and impact on the outcomes of IGF-1R and Livin in patients with colorectal cancerSemantic proximity Read

Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy.Semantic proximity Read

A Crispr Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis that Acts through Reduced mTOR SignallingSemantic proximity Read

LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal CancerSemantic proximity Read

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinomaSemantic proximity Read

IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cellsSemantic proximity Read

Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathwaySemantic proximity Read