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Article

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

5 Nov 2019

Abstract excerpt

Myocardin-related transcription factor B (MRTFB) is a candidate tumor-suppressor gene identified in transposon mutagenesis screens of the intestine, liver, and pancreas. Using a combination of cell-based assays, in vivo tumor xenograft assays, and Mrtfb knockout mice, we demonstrate here that MRTFB is a human and mouse colorectal cancer (CRC) tumor suppressor that functions in part by inhibiting cell invasion and...

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PMID: 31690663
DOI: 10.1073/pnas.1910413116

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