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Transcriptomic Analyses and Novel Organoid and Xenograft Modeling Reveals Potential Drug Sensitivities in a KRAS G12V-Mutant Colorectal Cancer Brain Metastasis

2024-10-11

Abstract excerpt

<title>Abstract</title> <p>Brain metastases (BM) occur in 2.3% of patients with colorectal cancer (CRC), which is the second leading cause of cancer deaths globally. Despite aggressive treatment like surgery and chemo-irradiation, median survival for patients with BM originating from CRC (CRC-BM) remains poor at 5.3 months, highlighting the need for improved therapies. Next-generation sequencing has identified <i...

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Literature Corpus work: e51cd277-bbb9-5f80-99aa-c12cb09c7a5a
DOI: 10.21203/rs.3.rs-5235115/v1

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