Article
Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.
Cancer research - 1 Mar 2018
Sakai Eri, Nakayama Mizuho, Oshima Hiroko, Kouyama Yuta, Niida Atsushi, Fujii Satoshi, Ochiai Atsushi, Nakayama Keiichi I, Mimori Koshi, Suzuki Yutaka, Hong Chang Pyo, Ock Chan-Young, Kim Seong-Jin, Oshima Masanobu
Abstract excerpt
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of specific mutations to different steps in malignant progression are not fully understood. In this study, we generated mouse models harboring different combinations of key colorectal cancer driver mutations (Apc, Kras, Tgfbr2, Trp53, Fbxw7) in intestinal epithelial cells to comprehensively investigate their roles in the...
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- Biomarkers, Tumor
- Disease Models, Animal
- Disease Progression
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Intestinal Neoplasms