Article

Anti-PD-1-iRGD Peptide Conjugate Boosts Antitumor Efficacy via Engagement Augmentation and Penetration Enhancement of T cells

2023-08-04

Abstract excerpt

Despite the important breakthroughs of immune-checkpoint inhibitors (ICIs) in recent years, the overall objective response rate (ORR) remains limited in various cancers. Here, we synthesized programmed cell death protein-1 (PD-1) antibody iRGD conjugate (αPD-1-(iRGD) 2 ) through glycoengineering and bio-orthogonal reaction. αPD-1-(iRGD) 2 exhibited extra iRGD receptor dependent affinity to several cancer cell li...

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Literature Corpus work: b1487895-90eb-5e27-838c-ac6d0ac7c7ac
DOI: 10.1101/2023.08.04.551949

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