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Signaling and functions of interleukin-33 in immune regulation and diseases

11 Jun 2022

Abstract excerpt

Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy and type 2 immunity. IL-33 transmits signals through its receptor IL-33R (also called ST2) which is expressed on the surface of T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s), thus inducing transcription of...

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PMID: 37192860
DOI: 10.1016/j.cellin.2022.100042

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