Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL11 activates the placental inflammasome to drive preeclampsia

24 May 2023

Abstract excerpt

Introduction Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Interleukin (IL)11 is elevated in serum from pregnancies that subsequently develop early-onset preeclampsia and pharmacological elevation of IL11 in pregnant mice causes the development of early-onset preeclampsia-like features (hypertension, proteinuria, and fetal growth restriction). However, the mechanism by which IL11...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammasome and immune disorders
Share to Pregnancy and preeclampsia studies
Share to Preterm Birth and Chorioamnionitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37292200
DOI: 10.3389/fimmu.2023.1175926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL11 activates the placental inflammasome to drive preeclampsiaPMID 37292200Read ↗

Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in PreeclampsiaSemantic proximity Read ↗

Placentas from Women with Late-Onset Preeclampsia Exhibit Increased Expression of the NLRP3 Inflammasome MachinerySemantic proximity Read ↗

The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast DysfunctionSemantic proximity Read ↗

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and PreeclampsiaSemantic proximity Read ↗

A clear and present danger: inflammasomes DAMPing down disorders of pregnancySemantic proximity Read ↗

The Inflammasome in Reproductive Biology: A Promising Target for Novel TherapiesSemantic proximity Read ↗

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsiaSemantic proximity Read ↗

Placental secretome characterization identifies candidates for pregnancy complicationsSemantic proximity Read ↗

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblastsSemantic proximity Read ↗

Potential regulatory network in the PSG10P/miR‐19a‐3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesisSemantic proximity Read ↗

The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse PregnancySemantic proximity Read ↗

IL11 stimulates IL33 expression and proinflammatory fibroblast activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.