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Article

IL-33 biology in cancer: An update and future perspectives

14 Jul 2022

Abstract excerpt

Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress, damage or necrosis, IL-33 is released into the cytoplasm to exert its prime role as an alarmin by binding to its specific receptor moiety, ST2. IL-33 exhibits pleiotropic function in inflammatory diseases and particularly in...

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PMID: 35843125
DOI: 10.1016/j.cyto.2022.155961

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