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A Nitric Oxide–Inducible Lactate Dehydrogenase Enables <i>Staphylococcus aureus</i> to Resist Innate Immunity

20 Mar 2008

Abstract excerpt

Staphylococcus aureus is one of the most successful human pathogens, colonizing 2 billion individuals worldwide and causing invasive infections even in immunocompetent hosts. S. aureus can evade multiple components of host innate immunity, including the antimicrobial radical nitric oxide (NO.) produced by activated phagocytes. We show that S. aureus is capable of metabolically adapting to nitrosative stress by...

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PMID: 18356528
DOI: 10.1126/science.1155207

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