Article

Immune protection and disease tolerance in <i>Pseudomonas aeruginosa</i> infections by pyruvate cross-feeding

2025-12-04

Abstract excerpt

Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not fully understood. Here, we identify a novel persistence mechanism mediated by pyruvate secretion resulting from mutations in the pyruvate dehydrogenase complex in clinical isolates of P. aeruginosa , with analogous...

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Literature Corpus work: 3a47fdb1-853e-5d68-9ec3-5788b65485dd
DOI: 10.64898/2025.12.04.692321

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