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Article

Immune protection and persistence in Pseudomonas aeruginosa infections by pyruvate cross-feeding.

Nature communications - 8 Jul 2026

Lampadariou Stefanos, Laborda Pablo, Masiero Lorenzo, Molin Søren, Johansen Helle Krogh, La Rosa Ruggero

Abstract excerpt

Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not fully understood. Here, we identify a persistence mechanism mediated by pyruvate secretion resulting from mutations in the pyruvate dehydrogenase complex in clinical isolates of P. aeruginosa, with putative...

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Haemophilus influenzae
Hydrogen Peroxide
Phagocytosis
Pseudomonas aeruginosa
Pseudomonas Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyruvate Dehydrogenase Complex

Stenotrophomonas maltophilia

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Identifiers

PMID: 42420271
DOI: 10.1038/s41467-026-75330-z
PMCID: PMC13478533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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