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Saturation-seq integrates single-cell saturation genome editing and RNA-seq to quantify NFE2L2 (NRF2) variant effects

2026-07-04

Abstract excerpt

Interpreting the functional consequences of variants remains one of the central unsolved problems in genomics and clinical genetics. Compounding this, most existing approaches rely on reductive, one-dimensional proxies such as cell growth to score variant effects, which can be a poor substitute for the rich, multidimensional phenotyping that is ultimately needed to understand how variants alter biology. This is es...

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Literature Corpus work: 0533fd74-fd72-5577-8c93-9109778d20ff
DOI: 10.64898/2026.06.30.735631

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Saturation-seq integrates single-cell saturation genome editing and RNA-seq to quantify <i>NFE2L2</i> (NRF2) variant effects

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