Article

Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stability

2026-07-17

Abstract excerpt

Vascular smooth muscle cells (VSMCs) drive atherosclerosis through phenotypic switching, yet their spatial organization and protein signatures within plaques remain poorly characterized. Here, we applied Deep Visual Proteomics (DVP) to dissect more than 500 VSMC neighborhoods across 24 human carotid plaques and profile VSMC plasticity in disease. To functionally interpret these tissue proteomes, we built a referen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9751e097-a782-503a-989a-d454375721d8
DOI: 10.64898/2026.07.17.738909

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stabilityDOI 10.64898/2026.07.17.738909Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

Decoding the transcriptome of atherosclerotic plaque at single-cell resolutionSemantic proximity Read

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic PlaquesSemantic proximity Read

Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques.Semantic proximity Read

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read

Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.Semantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease riskSemantic proximity Read

Integrated single-cell atlas of human atherosclerotic plaquesSemantic proximity Read

Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and OutcomesSemantic proximity Read

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populationsSemantic proximity Read