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Article

Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques.

Nature cardiovascular research - 1 Jul 2026

Sinha Ankit, Sachs Nadja, Kratz Elena, Pauli Jessica, Steigerwald Sophia, Albrecht Vincent, Nordmann Thierry M, Ugur Enes, Rodriguez Edwin H, Engl Marie-Luise, Skowronek Patricia, Oliinyk Denys, Metousis Andreas, von Scheidt Moritz, Wierer Michael, Winter Hanna, Schunkert Heribert, Branzan Daniela, Maegdefessel Lars, Mann Matthias

Abstract excerpt

Atherosclerotic plaque rupture is a major cause of cerebrovascular events, yet the molecular determinants underlying vulnerability-related plaque morphology, including fibrous-cap thickness, remain incompletely defined. Using histomorphology-guided spatial proteomics, here we delineate molecular programs associated with plaque cap phenotype across discrete plaque subregions. In 112 carotid endarterectomy...

Topics

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Carotid Arteries
Carotid Artery Diseases
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Atherosclerotic

Proprotein Convertase 9

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Open in PubMed Open full text

Identifiers

PMID: 42332205
DOI: 10.1038/s44161-026-00827-1
PMCID: PMC13368601

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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