Article
Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.
Neuro-degenerative diseases - 1 Jan 2010
Shen Jie
Abstract excerpt
Mutations in several causative genes have been linked to monogenic forms of Alzheimer's disease (AD) or Parkinson's disease (PD). To look for possible common pathogenic mechanisms underlying age-related neurodegeneration in AD and PD, we employed genetic approaches to investigate systematically the roles of these gene products (e.g. presenilins (PS) for AD; Parkin, DJ-1, PINK1 and LRRK2 for PD) in the mouse...
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