Article

Trisomy 21 cerebral organoids exhibit Alzheimer’s disease amyloid and apolipoprotein E co-pathologies

2026-07-07

Abstract excerpt

Adults with Down syndrome (DS) develop Alzheimer’s disease (AD) brain pathology by age 40 due to triplication of the Amyloid Precursor Protein ( APP ) gene on chromosome 21. Inheritance of the apolipoprotein E-e4 ( APOE4) allele of the APOE gene on chromosome 19 remains the greatest genetic risk factor for AD in the typical population, yet its role in DS-associated AD (DS-AD) neuropathogenesis in people with DS...

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Literature Corpus work: ee1004f7-1ae9-5de7-82ba-b070c0ece6e8
DOI: 10.64898/2026.07.01.735908

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