Article
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.
Acta neuropathologica communications - 27 Oct 2017
Ortiz-Virumbrales Maitane, Moreno Cesar L, Kruglikov Ilya, Marazuela Paula, Sproul Andrew, Jacob Samson, Zimmer Matthew, Paull Daniel, Zhang Bin, Schadt Eric E, Ehrlich Michelle E, Tanzi Rudolph E, Arancio Ottavio, Noggle Scott, Gandy Sam
Abstract excerpt
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol to generate human BFCNs from iPSCs, using cell lines from presenilin 2 (PSEN2) mutation carriers and controls. As expected, cell lines harboring...
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