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Article

Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Sept 2003

Abe Yoichiro, Kouyama Keisuke, Tomita Taisuke, Tomita Yusuke, Ban Norimitsu, Nawa Mikiro, Matsuoka Masaaki, Niikura Takako, Aiso Sadakazu, Kita Yoshiko, Iwatsubo Takeshi, Nishimoto Ikuo

Abstract excerpt

It is impossible to obtain and amplify live neurons from Alzheimer's disease (AD) patients. To establish the neurons harboring AD abnormality, we constructed mouse embryonic stem (ES) cells, in which the AD-causative V642I mutation was introduced to the endogenous amyloid precursor protein (APP) gene, in combination with a protocol to efficiently differentiate ES cells into postmitotic neurons without using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 13679420
PMCID: PMC6740361

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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