Article

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegeneration

2018-09-17

Abstract excerpt

We describe construction and phenotypic analysis of a human embryonic stem cell model of progressive Aβ-dependent neurodegeneration (ND) with potential relevance to Alzheimer’s disease (AD). We modified one allele of the normal APP locus to directly express a secretory form of Aβ40 or Aβ42, eliminating the need for amyloidogenic APP proteolysis. Following neuronal differentiation edited cell lines specifically acc...

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Literature Corpus work: 565ddf11-65b5-526d-97c4-60bc28b0b0fb
DOI: 10.1101/419978

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