Article

Spatial transcriptomics defines the mechanisms of hiPSC-derived stem cell-mediated repair in human articular cartilage

2026-07-23

Abstract excerpt

<h4>ABSTRACT</h4> We here determined therapeutic efficacy and mode-of-action of human induced pluripotent-derived therapeutic stem cells (hiMSCs) across in vivo mouse and ex vivo human osteoarthritis models. hiMSC treatment in DMM-mice significantly reduced OARSI damage scores, which was affirmed by a decrease in the catabolic marker Mmp13 and an increase in the anabolic marker Col2. These treatment effects app...

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Literature Corpus work: 087c73d3-4724-57fe-a059-36618b93abf0
DOI: 10.64898/2026.07.22.740000

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