Article

A Modular Bioinstructive Platform for Additive-Free, Topography-Driven Stem Cell Differentiation and Patterning

2025-07-14

Abstract excerpt

Recreating 3D bone formation in vitro without biochemical inducers remains a longstanding challenge in preclinical testing. We present a scalable, bioinstructive platform based on polylactic acid microparticles with controlled dimpled surface features that direct mesenchymal stem cell differentiation through endogenous topography-mediated mechanotransduction, establishing a mechanistically validated, additive-free...

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Identifiers and source

Literature Corpus work: 04338d8a-8650-5074-8227-ff7d1609a005
DOI: 10.1101/2025.07.11.664383

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