Article

Sphingolipid production by gut Bacteroidetes regulates glucose homeostasis

2019-05-09

Abstract excerpt

Levels of Bacteroidetes in the gut microbiome are positively associated with insulin resistance (IR) in humans. Considering that IR is promoted by elevations in hepatic sphingolipids (SL), particularly ceramides, and that Bacteroidetes are the only microbiome phylum possessing genes encoding serine palmitoyltransferase (SPT), which mediates SL synthesis, we investigated a potential link between bacterial SL produc...

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Literature Corpus work: 9cbfdada-8d15-5e7d-a183-6242a5003a61
DOI: 10.1101/632877

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