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Article

LSD1 promotes secretory cell specification to drive <i>BRAF</i> mutant colorectal cancer

2020-09-25

Abstract excerpt

Despite the connection to distinct mucus-containing colorectal cancer (CRC) histological subtypes, the role of secretory cells, including goblet and enteroendocrine (EEC) cells, in CRC progression has been underexplored. Analysis of TCGA and single cell RNA sequencing data demonstrates that multiple secretory progenitor populations are enriched in BRAF- mutant CRC patient tumors and cell lines. Enrichment of EEC...

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Literature Corpus work
96b829bb-94c6-5ee1-9b5e-6a6c5f62d1a3
DOI
10.1101/2020.09.25.313536
Open publication

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LSD1 promotes secretory cell specification to drive <i>BRAF</i> mutant colorectal cancerDOI 10.1101/2020.09.25.313536
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