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The emerging roles of deep crypt secretory cells in colonic physiology

12 Sept 2023

Abstract excerpt

Deep crypt secretory (DCS) cells are a population of epithelial cells located at the colonic crypt base that share some similarities to Paneth and goblet cells. They were initially defined as c-Kit expressing cells, though subsequent work showed that they are more specifically marked by Reg4 in the murine colon. The best-understood function of DCS cells at present is supporting the stem cell niche by generating...

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PMID: 37697924
DOI: 10.1152/ajpgi.00093.2023

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