Article

LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in <i> BRAF <sup>V600E</sup> </i> colorectal cancer

2024-10-29

Abstract excerpt

BRAF activating mutations occur in approximately 10% of metastatic colorectal cancer (CRCs) and are associated with worse prognosis due to an inferior response to standard chemotherapy. Standard of care for patients with refractory metastatic BRAF V600E CRC is treatment with BRAF and EGFR inhibitors. However, responses are not durable. Lineage plasticity to neuroendocrine cancer is an emerging mechanism of targe...

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Literature Corpus work: b8b8538c-b7f0-535e-9171-ec219cd88267
DOI: 10.1101/2024.10.25.620306

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