Article

GSTT1 mediates stemness and FGFR inhibitor sensitivity in pancreatic cancer through regulation of CD133 ( <i>PROM1</i> )

2025-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDA) is among the deadliest malignancies, driven by metastatic progression and profound cellular heterogeneity. We previously identified glutathione S-transferase theta 1 (GSTT1) as a regulator of a slow-cycling, highly metastatic tumor cell population, suggesting that GSTT1 High cells may possess stem-like properties. Here, we define the functional and molecul...

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Literature Corpus work: 3ac3e04f-3173-5071-b4fd-be8bd991390f
DOI: 10.1101/2025.08.06.668944

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