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A <i>trans</i> -translation inhibitor is potentiated by zinc and kills <i>Mycobacterium tuberculosis</i> and non-tuberculous mycobacteria

2024-11-02

Abstract excerpt

<h4>SUMMARY</h4> Mycobacterium tuberculosis poses a serious challenge for human health, and new antibiotics with novel targets are needed. Here we demonstrate that an acylaminooxadiazole, MBX-4132, specifically inhibits the trans -translation ribosome rescue pathway to kill M. tuberculosis . Our data demonstrate that MBX-4132 is bactericidal against multiple pathogenic mycobacterial species and kills M. tuberc...

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Literature Corpus work
96ae614f-ce70-5185-b6b9-88c4fc12ab36
DOI
10.1101/2024.11.02.621434
Open publication

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A <i>trans</i> -translation inhibitor is potentiated by zinc and kills <i>Mycobacterium tuberculosis</i> and non-tuberculous mycobacteriaDOI 10.1101/2024.11.02.621434
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