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Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

1 Sept 2011

Abstract excerpt

Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey of intracellular mycobacteria and their host macrophages revealed signatures of heavy metal poisoning. In particular, mycobacterial genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and...

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PMID: 21925112
DOI: 10.1016/j.chom.2011.08.006

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